Testing Maternal-Fetal Genotype Incompatibility With Mother-Offspring Pair Data
نویسندگان
چکیده
1. Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, Michigan 48824 USA 2. Division of Biostatistics, Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, 72202 USA 3. Department of Statistics and Probability, Michigan State University, East Lansing, Michigan 48824 USA 4. Department of Mathematical Science, Peking University, Beijing, China 100871 5. Perinatology Research Branch, NICHD/NIH, Hutzel Women’s Hospital, Detroit, Michigan 48201 USA
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Using the maternal-fetal genotype incompatibility test to assess non-inherited maternal HLA-DRB1 antigen coding alleles as rheumatoid arthritis risk factors
Non-inherited maternal antigens encoded by specific HLA-DRB1 alleles (NIMA) have been implicated as a rheumatoid arthritis (RA) risk factor. Using genotype data from North American Rheumatoid Arthritis Consortium study participants and the maternal-fetal genotype incompatibility (MFG) test, we find evidence for offspring allelic effects but no evidence for NIMA as a RA risk factor. We discuss p...
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